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Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression In Rheumatoid Arthritis Models By Selective Inhibition Of The Immunoproteasome
Proteolix, Inc. announced that in an article published in Nature Medicine, Proteolix"s selective immunoproteasome inhibitor PR-957 was shown to block disease progression in mouse models of rheumatoid arthritis in a dose-dependent manner and to completely eliminate visible signs of disease at the highest dose. The anti-inflammatory effect induced by PR-957 was rapid and long-lasting, lowering expression of multiple inflammatory mediators, including TNF-a and IL-6. Disease regression was evident 24 hours after dosing and a complete amelioration of disease was achieved with a single dose. When compared to anti-TNF-a therapy (etanercept), PR-957 mediated a more rapid resolution of clinical symptoms, including joint inflammation, and was more effective than etanercept in a model of aggressive arthritis.
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Ways And Means Committee Passes Reform Bill, Prepares For Fight
The House Ways and Means Committee passed the House version of a health care reform bill early Friday morning, approving as much as a 5.4 percent surtax on the wealthy to pay for it and readying for a fight, Bloomberg reports.
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Abraxis Bioscience Completes Enrollment Of Pivotal Phase III Advanced Lung Cancer Study Evaluating Abraxane(R) Vs. Taxol(R)
Abraxis BioScience, Inc. (NASDAQ:ABII), a fully integrated biotechnology company, announced that the company has completed patient enrollment of a pivotal, phase III clinical study comparing the company"s chemotherapy agent ABRAXANE® for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin bound) with Taxol® (paclitaxel) injection, both in combination with carboplatin, in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC). The study, which is being conducted at 111 sites globally, includes 1,050 patients and is being led by principal investigator Dr. Mark Socinski at the University of North Carolina Lineberger Comprehensive Cancer Center. It is one of the largest NSCLC clinical studies to complete enrollment.
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Surveys Show GPs Need More Support - Australian Medical Association

A study which found up to one third of GPs are planning to retire early highlights the need for governments to boost support for general practice, AMA Federal President, Dr Andrew Pesce, said today. The results of a survey of 178 West Australian GPs aged 45-65 years showed one third of respondents intended to retire before the age of 65. The results were published in the Medical Journal of Australia as the AMA prepared to mark GP Week from 20-26 July. Survey participants cited exhaustion and burnout, increasing bureaucracy, poor job satisfaction and disillusionment with the health system or Medicare as obstacles to working in General Practice. Dr Pesce said it would be devastating for general practice if a similar proportion of the GP workforce in other states decided to retire early. "General practice is the cornerstone of our health system and patients will suffer if overwork forces GPs to retire early," Dr Pesce said. "Most GPs love their jobs but overwork and stress - often linked to the current medical workforce shortage - is taking its toll. Doctors are also frustrated by the amount of time they are forced to spend completing paperwork instead of caring for patients." Dr Pesce said the Government should increase GP training places and incentives for experienced GPs to take on trainees. "Increasing the size of the medical workforce will take pressure off existing GPs," he said. "Extra Government investment is needed to help GP practices fund the infrastructure to accommodate trainees. The Government also needs to look at ways of reducing the amount of Medicare-related red tape GPs are forced to deal with. "The theme for GP Week this year is "There is no substitute." GPs provide comprehensive medical care to Australians of all ages. It"s true: We really can"t do without our GPs." Australian Medical Association


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