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New Study Helps Explain Why It Is Easy To Encode New Memories But Hard To Hold Onto Them
Memories aren"t made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. In the July 13, 2009 issue of the Journal of Cell Biology, Rex et al. reveal that LTP"s actin reorganization occurs in two stages that are controlled by different pathways, a discovery that helps explain why it is easy to encode new memories but hard to hold onto them.
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New Labor Ads Focus On Health Benefits Tax
"Much of the TV advertising on health care so far has focused on the controversial public, or government-run insurance program that Democrats say would compete with private insurers and Republicans say would drive them out of business," but the Laborers" International Union of North America "will begin airing ads in two states Tuesday that deal with an equally explosive issue: Taxing health benefits," USA Today reports. The union will "run the ads at least through Thursday in North Dakota and Montana," home states of "the two most important senators on the issue, Senate Finance Chairman Max Baucus, D-Mont., and Senate Budget Committee Chairman Kent Conrad, D-N.D." The ads reveal the "fine line labor is walking" on health care: "The ads first praise Congress for taking up the health care debate but then criticize an idea that could be included in one draft of the legislation to tax health care premiums" (Fritze, 6/29).
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Generation Of A Severe Memory-Deficit Mutant Mouse By Exclusively Eliminating The Kinase Activity Of CaMKIIalpha
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dependent synaptic plasticity and memory functions. However, the causative role of the enzymatic activity of CaMKII alpha in such processes has not been demonstrated yet, because this enzyme has multiple protein functions other than the kinase activity. A Japanese research group, led by Dr Yoko Yamagata of the National Institute for Physiological Sciences, Japan, has successfully generated a novel kinase-dead mutant mouse of the CaMKII alpha gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic plasticity and behavioral learning of the mouse, and found a severe deficit in both processes. They reported their findings in the Journal of Neuroscience, published on June 10, 2009.
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Exercise Is Healthy For Mom And Child During Pregnancy

Physicians should recommend low to moderate levels of exercise to their pregnant patients, even if they have not exercised prior to pregnancy, states a report published in the August 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS). According to this review article, exercise can strengthen and improve overall musculoskeletal and physiologic health as well as pregnancy related symptoms. Exercise such as aerobics, impact and nonimpact activities, resistance training and swimming: -- eases back and other musculoskeletal pain; -- lowers maternal blood pressure; -- reduces swelling; and -- improves post-partum mood, including sadness. According to study author Capt. Marlene DeMaio, M.D., M.C., U.S.N., Research Director, Naval Medical Center, Portsmouth, Virginia, data shows that the pregnant woman"s body can compensate for the changes with no harm to the fetus during low to moderate intensity exercise. "It is important to remember that pregnancy is a temporary condition, not a disease, and that the musculoskeletal and physiologic changes that happen are normal in the majority of patients," she said. Capt. DeMaio"s findings contradict what some physicians recommended in the past. As recently as the 1990s, there was concern that exercise could be detrimental to a pregnant woman and her fetus. These past concerns included a focus on normal changes related to musculoskeletal health that occur during pregnancy, such as increased ligament laxity, weight gain and change in the center of gravity. Today, some physicians continue to advise their pregnant patients to ease back on exercise or refrain from it altogether if they have not already made it a part of their lifestyle. DeMaio, who collaborated with Capt. Everett Magann, M.D., M.C. U.S.N., Chairman in the Department of Obstetrics and Gynecology, also at the Naval Medical Center in Portsmouth, not only reports that exercise is important during pregnancy, but also believes that starting an exercise program when pregnant, is a perfect way to begin - and stick with - a fitness program. "When a woman becomes pregnant, she often re-evaluates her lifestyle," said Dr. DeMaio. "She is motivated in a new way to deliver a healthy baby, and be healthy herself." Physicians may recommend exercise for pregnant patients in the following categories: -- Prenatal: Patients should begin or continue low to moderate exercise. The goal is to maintain fitness and adapt exercise as needed as pregnancy progresses. (For example, runners might switch to running in a swimming pool later in their pregnancy.) -- Postnatal: Continue exercising at low to moderate levels. Lactation is not negatively affected by exercise. There are fewer reports of mothers having post-partum depression or mood changes when they are exercising. -- Older: Exercise is even more important if the patient is older, according to Dr. DeMaio. The risk for high blood pressure and increased glucose goes up the older a patient is, but exercise can help reduce these levels. -- Obese: Physicians should discuss pregnancy as an opportunity to improve overall health and suggest the patient start exercise for life-long health and as an example to the child when the child is older. -- Infertile: Even if a woman is under treatment for infertility, she can exercise under the supervision of her obstetrician. -- Athlete: For a pregnant woman wanting more strenuous exercise, or who wants to increase training from moderate to high intensity, a qualified doctor should direct her exercise program. Disclaimer: The views expressed in this article are those of the author(s) and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense or the United States Government. Dr. DeMaio serves as a board member of the Association of Bone and Joint Surgeons and the publications American Journal of Sports Medicine and Clinical Orthopaedics and Related Research in an unpaid capacity. Neither Dr. Magann nor a member of his immediate family has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article. American Academy of Orthopaedic Surgeons


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