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SCRIP's 'Best-In-Class' Reporting Recognised By Industry - Journalist Malani Guha Wins Advances In Renal Cancer Journalists' Award
Journalist, Malini Guha, has won the prestigious new Advances in Renal Cancer Journalists" Award - Europe for her article "New Advances Deliver Fresh Hope in Kidney Cancer" - which was published in Scrip World Pharmaceutical News on February 13th 2009.
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Earlier Surgery Recommended For RA Patients
A new study published by the American Society of Plastic Surgeons reveals that one of the most common conditions caused by Rheumatoid Arthritis (RA) is best treated surgically, sooner rather than later. Patients with RA frequently experience a debilitating condition known as metacarpophalangeal joint disease, which is usually treated by replacing the knuckle joints with solid silicone joints. However, this treatment (and others like it) has spurred great disagreement between hand surgeons and rheumatologists regarding the indications, timing and perceived outcomes of the procedure; rheumatologists tend to refer late-stage patients for surgery whereas hand surgeons believe that earlier intervention can yield more positive outcomes.
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Sotomayor 'Clearly Belongs' On Supreme Court, NYT Editorial Says
Despite "the flimsy arguments" that some Republicans on the Senate Judiciary Committee made for opposing the confirmation of Supreme Court nominee Sonia Sotomayor, she "clearly belongs on the court," a New York Times editorial states. Although Sotomayor sometimes avoided "forthright answers on important legal issues" during the confirmation hearings, she consistently "showed an impressive command of the law," according to the editorial.Claims that Sotomayor would not be able to resist "judicial activism" and that she would be "overly influenced by "personal preferences"" if she were to serve on the court are "strikingly weak," the editorial states. It continues, "Some Republicans may be wary of opposing Judge Sotomayor because she would be the first Hispanic justice, and they are reluctant to alienate a large voting bloc," but "[t]here is no need for political calculations." According to the editorial, "Senators should support her because she is eminently qualified."The editorial states, "We hope the vote in the full Senate for Judge Sotomayor will be overwhelming and the rhetoric more high-minded" (New York Times, 8/2).
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Defeating Nicotine's Double Role In Lung Cancer

A lung cancer treatment that inhibits nicotine receptors was shown to double survival time in mice, according to Italian researchers. The results of the early phase animal model study were reported in the June 15 issue of the American Journal of Respiratory and Critical Care Medicine. Changes in genes encoding nicotine receptors are strongly associated not only with the tendency to smoke, but with susceptibility to lung cancer. Nicotine exposure also heightens the expression of the nicotine receptors, which leads to increased cell proliferation and inhibition of apoptosis, further setting the stage for cancer. Patrizia Russo, Ph.D. and Laura Paleari, Ph.D. of the Lung Cancer Unit of the National Cancer Research Institute in Genoa, Italy and colleagues from San Raffaele Pisana Scientific Institute for Research, Hospitalization and Health Care (IRCCS), Catholic University, Campus Biomedico University in Rome, Mario Negri Institute in Milan and CEA Gyf sur Yvette in France showed in past research that an antagonist of nicotine acetylcholine receptors (nAChRs), may serve as an anticancer agent. The antagonist, called d-tubocurarine/í±-Cobratoxin (í±-CbT), specifically targeted the í±7 subunit of nAChRs, the area primarily associated with increased cell proliferation. In this study, the authors took the research a step further and showed that í±-CbT could inhibit non-small cell lung carcinoma (NSCLC) growth and prolong life in non-obese/severe combined immunodeficient (NOD/SCID) mice that had human NSCLC grafted to their lungs. This study attempted to mimic human cancer conditions more closely by delaying treatment until the tumors were well-established. In addition to control mice that were untreated, the researchers randomized one third of the mice to receive standard chemotherapy. They found that NOD/SCID mice treated with the standard chemotherapy agent, cisplatin, had a 16 percent longer median survival time than untreated mice (p= 0.05). Mice treated with í±-CbT, however, had an increased median survival time of 1.7-fold over the cisplatin-treated mice and 2.1-fold over the no-treatment controls (p=0.0005). "The results of this study show that í±-CbT, a powerful, high-affinity í±-7-nAChR inhibitor, induces antitumor activity against NSCLC by triggering apoptosis," wrote Dr. Russo. "The prolonged survival of í±-CbT-treated animals in our mouse model of NSCLC is most likely the result of several mechanisms, including various antiproliferative and antiangiogenic effects." The research also found that unaffected (i.e., noncancerous) cells showed no inhibition of proliferation when treated with í±-CbT, suggesting that the treatment would have limited if any toxic effects. Dr. Russo and colleagues postulated that this finding may be due to the reduced number of receptor binding sites on normal cells as opposed to cancerous cells. Conversely, they reported that cancer cells with the greatest number of receptor binding sites seemed to respond with the greatest sensitivity to the treatment. "The goal of this research line is to explore the widest range of possibilities of intervention on the΀  í±7-nAChRs. We hope to move further on towards the clinical setting experimentation phase for the assessment of potentially new treatment strategies for NSCLC," said Dr. Russo. An editorial in the same issue of the journal asked if nicotine may be to lung cancer what estrogen is to breast cancer. Eliot R. Spindel, M.D., Ph.D., of Oregon Health & Science University, stated that estrogen can stimulate the development of breast cancer and estrogen-receptor antagonists, such as tamoxifen, provide therapeutic benefit. In support of a carcinogenic role for estrogen, the incidence of breast cancer appears to be decreasing as estrogen hormone replacement therapy is being used less often. Likewise, nicotine may promote lung cancer yet nicotine receptor antagonists may offer treatment options for patients with lung cancer. John Heffner, M.D., past president of the ATS stated that "this research clearly has profound clinical implications regarding the role of nicotine in stimulating lung cancer and nicotine receptor antagonists in treating the disease. The highly addictive nature of nicotine, however, complicates patients" ability to quit smoking and avoid ongoing nicotine exposure." "This [addictive nature of nicotine] underscores the importance of potential FDA regulation of nicotine in tobacco products to limit exposure to this drug that promotes tumor growth," wrote Dr. Spindel. American Thoracic Society


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