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Anti-dumping Duties Detrimental For UK Farming, NFU Tells Review
The NFU has told a European Commission review of anti-dumping duties imposed on fertiliser from the Ukraine that such measures act as artificial trade barriers and, given the importance of fertiliser to agriculture, can curb profitability of farms across the UK and EU.
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Novel Clinical Practice Guideline Manual Released By ENT Society
The world"s largest ear, nose, and throat professional medical association, the American Academy of Otolaryngology - Head and Neck Surgery (AAO-HNS), has released a manual detailing best practices for the creation of new clinical practice guidelines. The manual is published as a supplement to the June issue of Otolaryngology - Head and Neck Surgery.
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White House Budget Chief Says Issue Of Abortion Coverage In Health Reform Still Under Debate
In an appearance on "Fox News Sunday," White House Office of Management and Budget Director Peter Orszag said that he is "not prepared to say explicitly" whether health care reform legislation would prohibit the use of federal tax revenue to fund abortion coverage, the New York Times reports. Orszag"s statement came in reply to a question asking whether he was prepared to say that "no taxpayer money will go to pay for abortions." Orszag said, "It"s obviously a controversial issue, and it"s one of the questions that is playing out in the debate" (Pear/Liptak, New York Times, 7/20).Sen. Judd Gregg (R-N.H.), who also appeared on "Fox News Sunday," said, "No matter what your views are on abortion, you shouldn"t ask people to use their tax dollars if they think that abortion is taking a life." Gregg added, "I would hate to see the health care debate go down over that issue. We do really need health care reform, and it has to be substantive. ... So hopefully we won"t get ourselves wrapped around the wheel of abortion in this debate" (FoxNews.com, 7/19). According to the Times, there is an ongoing behind-the-scenes debate over handling abortion coverage in health overhaul legislation. The debate affects both the public insurance plan the legislation would create and private insurers, who would receive tens of billions of dollars in federal subsidies to expand coverage for low- and moderate-income U.S. residents. A provision in the House health reform bill (HR 3200) calls for a federal advisory committee to advise the HHS secretary on an "essential benefits package" that most insurers would be required to provide. Abortion-rights opponents want abortion coverage excluded from the package, while abortion-rights advocates say the decision should be left to medical professionals. House committees working on health reform legislation have rejected Republican amendments that would have restricted abortion coverage. The Hyde Amendment, first enacted in 1976, prohibits the use of federal Medicaid money for abortion services. However, abortion-rights opponents argue that federally subsidized coverage of the uninsured would not be subject to the existing restrictions. The National Right to Life Committee issued an analysis of the House bill, stating, "There is no doubt that coverage of abortion will be mandated, unless Congress explicitly excludes abortion from the scope of federal authority to define "essential benefits."" According to the group, even if the HHS secretary did not require abortion coverage, "federal courts would interpret the broadly worded mandatory categories of coverage to include abortion" (New York Times, 7/20).
Nutrition

Bacteria Are First Sensed By Cells Lining Blood Vessels, Not Immune Cells

Paul Kubes and colleagues, at the University of Calgary, Canada, have provided evidence in mice to refute the paradigm that the initial phase of the immune response to infection with Gram-negative bacteria (the recruitment of immune cells known as neutrophils to the site of infection) is triggered following immune sentinel-cell recognition of the bacterial molecule LPS via the protein TLR4. Rather, the researchers found that LPS recognition by TLR4 on the cells that line blood vessels (endothelial cells) is the crucial event that initiates neutrophil recruitment and bacterial clearance in mice. In the study, mice engineered such that they expressed TLR4 exclusively on endothelial cells were found to be dramatically less susceptible to a lethal intraperitoneal dose of the bacterium E. coli than normal mice. This was because neutrophil recruitment to the site of infection was much more efficient in the engineered mice than in normal mice, as a result of many neutrophils being sequestered in the blood vessels of the lungs of normal mice. In contrast, TLR4 on endothelial cells was not involved in neutrophil recruitment following LPS administration into the airways, rather TLR4 on immune sentinel cells was the key trigger of neutrophil recruitment. The authors therefore conclude that TLR4 on endothelial and immune sentinel cells is crucial for infection with Gram-negative bacteria at different sites, the blood and tissues, and the lungs, respectively. TITLE: Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection AUTHOR: Paul Kubes University of Calgary, Calgary, Alberta, Canada. View the PDF of this article at: https://www.the-jci.org/article.php?id=36411 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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