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Provectus Reports Encouraging Clinical Data At ASCO On Treatment Of Metastatic Melanoma With PV-10
Provectus Pharmaceuticals, Inc. (OTC Bulletin Board: PVCT), a development-stage oncology and dermatology biopharmaceutical company, has announced interim data from the first 40 subjects in its Phase 2 clinical trial for the treatment of metastatic melanoma. PV-10 treatment was well tolerated and caused selective tumor destruction in the majority of subjects. Additional data on untreated tumors corroborated observations of a possible bystander effect seen during earlier Phase 1 testing. These data were presented today at the American Society of Clinical Oncology 2009 Annual Meeting, Abstract #9060, entitled "Chemoablation of melanoma with intralesional rose bengal (PV-10)," in the General Poster Session.
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Obama Urges Swift Confirmation Of Sotomayor; GOP Mulls Opposition Strategy
President Obama on Tuesday in his official announcement of his nomination of Judge Sonia Sotomayor of the Second Circuit Court of Appeals to the Supreme Court emphasized what he called her "extraordinary journey" from a modest background to the top of the judiciary, launching a "confirmation battle that he hopes to wage over biography more than ideology," the New York Times reports. If confirmed, Sotomayor would be the first Hispanic and the third woman to serve on the court, as well as the sixth of the court"s current members with a Roman Catholic background, the Times reports (Baker/Zeleny, New York Times, 5/27). Sotomayor would replace retiring Justice David Souter, who typically is a liberal vote on social issues, the Wall Street Journal reports. Therefore, the addition of Sotomayor would not likely change the ideological balance of the court (Bravin/Koppel, Wall Street Journal, 5/27). The Washington Post reports Obama in his remarks cast Sotomayor "as the embodiment of the qualities he seeks in a judge," including superior intelligence, an understanding of the limited role of the judiciary and what he called "an understanding of how the world works and how ordinary people live" (Barnes/Fletcher, Washington Post, 5/27). The president said he wants Sotomayor to be confirmed before the Senate leaves in August for its summer recess, so she can join the court in time for its September review of potential cases. White House Press Secretary Robert Gibbs said that the Senate has "ample time" to complete the confirmation process, as the average time span is 72 days and there are 74 until the recess (Koffler, Roll Call, 5/26). Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) praised Obama"s decision, calling Sotomayor"s record "exemplary" and her nomination "historic." Leahy noted that both former President George H.W. Bush and former President Clinton nominated Sotomayor to federal judgeships, adding, "She has been nominated by both Democratic and Republican presidents, and she was twice confirmed by the Senate with strong, bipartisan support" (Stanton, Roll Call, 5/26).Rulings on Abortion Rights Throughout her career as a federal judge, Sotomayor has not issued what are considered major decisions regarding abortion rights, although her record on cases involving civil and social rights issues appear "more liberal than not," according to the New York Times (Liptak, New York Times, 5/27). Politico reports that Sotomayor has ruled in favor of antiabortion-rights groups in two cases. The first case occurred in 2002 when she sided with the Bush administration in its efforts to implement the "global gag rule," which banned federal funding for international family planning groups that offer abortion services or information with their own funds. Sotomayor ruled that the government had the right to decide how to spend its funding. In 2004, Sotomayor ruled in favor of antiabortion-rights protesters who alleged that they were brutalized while being arrested in West Hartford, Conn. (Gerstein/Javers, Politico, 5/26). Gibbs said that Obama did not ask Sotomayor about issues related to abortion during her vetting and there was "no litmus test" on abortion-rights issues (Koffler, Roll Call, 5/26).Obama"s announcement was well-received by many groups that support abortion rights. NARAL Pro-Choice America President Nancy Keenan said the group is anticipating more information about Sotomayor"s views on abortion rights and the right to privacy. She added that the group is "encouraged by the strong support she receives from her peers and other legal scholars and the fact that the Senate has twice confirmed her for federal judgeships" (Posner, Congress Daily, 5/26). Kim Gandy, president of the National Organization of Women, said that Sotomayor "brings a lifelong commitment to equality, justice and opportunity, as well as the respect of her peers, unassailable integrity and a keen intellect informed by experience." Gandy added that Obama "said he wanted a justice with "towering intellect" and a "common to
News of the day
More Community Health Care Now, That's The Remedy For Our Ailing Hospitals, Australia
In response to the Australian Institute of Health and Welfare (AIHW) report on hospitals, Australian Nursing Federation (ANF) said the best remedy for Australia"s hospitals is to keep people out of them.
Diagnostics

Babies With Mild Facial Paralysis From Forceps Typically Do Not Need Treatment

Mild facial nerve paralysis caused by the use of forceps during birth generally resolves on its own and does not require treatment, according to a report in the July issue of Archives of Otolaryngology-Head & Neck Surgery, one of the JAMA/Archives journals. Facial nerve palsy (inability to move some facial muscles) occurs in approximately 0.8 to 7.5 of 1,000 births overall and 8.8 of every 1,000 births in which forceps are used, according to background information in the article. "Previous observations indicate that while most cases of facial nerve palsy caused by birth trauma implicate the use of forceps, up to 33 percent occur in spontaneous vaginal delivery without instrumentation," the authors write. The injury is caused when the forceps blade or a bone in the mothers" pelvis puts pressure on the baby"s head in the area of the facial nerve. Melanie Duval, M.D., of McGill University, Montreal, Quebec, Canada, and Sam J. Daniel, M.D., M.Sc., F.R.C.S.C., of McGill University and Montreal Children"s Hospital, reviewed the medical records of 28 babies with facial nerve palsy caused by forceps use between 1989 and 2005. In all 28 cases, the palsy was classified as mild to moderate. "Except in one neonate, no treatment was initiated in any of the patients," the authors write; one child received a 14-day course of oral prednisone, a corticosteroid. "All 21 neonates with adequate long-term follow-up recovered fully after an average period of 24 days." "There is discrepancy in the literature on the investigations and/or treatment options to be undertaken in facial palsy owing to birth trauma," the authors conclude. Some authors recommend surgery to explore the nerve, whereas most consider observation to be sufficient in uncomplicated cases. The current results add to evidence that the recovery rate is high without treatment. "This confirms that corticosteroid treatment or surgery should be withheld in neonates presenting with uncomplicated facial nerve palsy resulting from forceps trauma." Arch Otolaryngol Head Neck Surg. 2009;135[7]:634-636. Archives of Otolaryngology-Head & Neck Surgery


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