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Getting Obese Mice Moving And Curing Their Diabetes
Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic - not to mention downright sluggish. Now, a new study in the June Cell Metabolism shows that blood sugar control in those animals can be completely restored by returning leptin sensitivity to a single class of neurons in the brain, which account for only a small fraction of those that normally carry the hormone receptors.
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Pfizer's Oral JAK-3 Inhibitor Demonstrates Statistically Significant Response For Patients With Rheumatoid Arthritis, New Phase 2 Studies Show
Pfizer announced today that data from two new mid-stage clinical studies of the company"s oral JAK-3 inhibitor, CP-690,550, showed statistically significant response versus placebo for patients with rheumatoid arthritis (RA). Data from these two Phase 2 trials and one ongoing open-label safety study are being presented this week at the 10th Annual Congress of the European League Against Rheumatism (EULAR). These results confirm findings from two previously reported Phase 2 studies in RA and have been used to support dose selection for Phase 3.
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Ventana's Promising New Anti-Obesity Patent
Ventana Biotech Inc ("Ventana")(PINK SHEETS:VNTA), a biotechnology company that is developing a appetite-suppressing chewing gum, released detailed information about its innovative Anti-Obesity Chewing Gum.

Sotomayor 'Clearly Belongs' On Supreme Court, NYT Editorial Says.

Despite "the flimsy arguments" that some Republicans on the Senate Judiciary Committee made for opposing the confirmation of Supreme Court nominee Sonia Sotomayor, she "clearly belongs on the court," a New York Times editorial states. Although Sotomayor sometimes avoided "forthright answers on important legal issues" during the confirmation hearings, she consistently "showed an impressive command of the law," according to the editorial.Claims that Sotomayor would not be able to resist "judicial activism" and that she would be "overly influenced by "personal preferences"" if she were to serve on the court are "strikingly weak," the editorial states. Moscow a forum

Researchers Identify New Method To Selectively Kill Metastatic Melanoma Cells.

An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma - a cancer that is highly resistant to current treatment strategies. Researchers from Virginia Commonwealth University, in collaboration with a team of researchers led by Maria S. Soengas, Ph.D., with the Spanish National Cancer Research Center in Madrid, Spain, found that activation of a specific molecular pathway triggers melanoma cells to begin a process of self-destruction - through self-digestion and programmed cell death. The study is published in the August 4 print issue of the journal Cancer Cell. recover Outlook Express dbx

Academy Makes Recommendations To Build Clinical Academic Capacity.

UK clinical research is currently benefiting from significant additional investment from Government and other research funders. A challenge for funders and institutions is to allocate res across the range of clinical academic specialties, to most effectively pursue research and its translation into improved healthcare. The Academy"s Clinical Academic Careers Committee, chaired by Professor Patrick Sissons FMedSci, has published a report providing guidance on how funding and re should be used to support clinical academic specialties. contactos

Smoking, High Blood Pressure And Diabetes In Mid-life Can Lead To Dementia.

Middle aged people who smoke, have high blood pressure or diabetes are far more likely to develop dementia in later life, suggests research published ahead of print in the Journal of Neurology, Neurosurgery and Psychiatry. People should consider modifying their lifestyle in mid-life to avoid developing dementia, claims the US research. Dementia is a growing public health problem affecting older people in developed countries. In the US, where the research took place, estimates show that one in six people older than 70 have dementia. Estimates are that the number of people with dementia will grow threefold by 2050, compared with 2000. Buy zoloft online and forget about depression.